Publications
2025
A unified framework for hydromechanical signaling can explain transmission of local and long-distance signals in plants.
V. Bacheva, F.E. Rockwell, J. Salmon, J.D. Woodson, M.H. Frank, & A.D. Stroock
Proc. Natl. Acad. Sci. U.S.A. 122 (17) e2422692122, https://doi.org/10.1073/pnas.2422692122 (2025).
Transdisciplinary Collaborations for Advancing Sustainable and Resilient Agricultural Systems.
Bacheva, V., Madison, I., Baldwin, M., Baker, J., Beilstein, M., Call, D.F., Deaver, J.A., Efimenko, K., Genzer, J., Grieger, K., Gu, A.Z., Ilman, M.M., Liu, J., Li, S., Mayer, B.K., Mishra, A.K., Nino, J.C., Rubambiza, G., Sengers, P., Shepherd, R., Woodson, J., Weatherspoon, H., Frank, M., Jones, J.L., Sozzani, R. and Stroock, A.D.
(2025), Glob Change Biol. https://doi.org/10.1111/gcb.70142
Re-analysis of mobile mRNA datasets raises questions about the extent of long-distance mRNA communication.
Pirita Paajanen, Melissa Tomkins, Franziska Hoerbst, Ruth Veevers, Michelle Heeney, Hannah Rae Thomas, Federico Apelt, Eleftheria Saplaoura, Saurabh Gupta, Margaret Frank, Dirk Walther, Christine Faulkner, Julia Kehr, Friedrich Kragler, Richard J Morris.
Nat. Plants (2025). https://doi.org/10.1038/s41477-025-01979-x
2024
Graft incompatibility between pepper and tomato elicits an immune response and triggers localized cell death.
Hannah Rae Thomas, Alice Gevorgyan, Alexandra Hermanson, Samantha Yanders, Lindsay Erndwein, Matthew Norman-AriztÃa, Erin E Sparks, Margaret H Frank
Horticulture Research, Volume 11, Issue 12, December 2024, uhae255, https://doi.org/10.1093/hr/uhae255
A transcriptional dissection of the petty spurge (Euphorbia peplus L.) reproductive structure
Arielle Rose Johnson, Ashley Bao, Margaret Hannah Frank
bioRxiv 2024.05.06.592779; https://doi.org/10.1101/2024.05.06.592779
Pluripotency of a founding field: rebranding developmental biology.
Development 1 February 2024; 151 (3): dev202342. doi: https://doi.org/10.1242/dev.202342
2023
Anatomical and biophysical basis for graft incompatibility within the Solanaceae.
Hannah R Thomas, Alice Gevorgyan, Margaret H Frank
Journal of Experimental Botany, Volume 74, Issue 15, 17 August 2023, Pages 4461–4470, https://doi.org/10.1093/jxb/erad155
Highlighted in Science Magazine: https://www.science.org/doi/10.1126/science.adk9203
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Introduction of barnase/barstar in soybean produces a rescuable male sterility system for hybrid breeding.
Szeluga, N., Baldrich, P., DelPercio, R., Meyers, B. C., & Frank, M. H.
Plant Biotechnology Journal. https://doi.org/10.1111/pbi.14155
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The mRNA mobileome: challenges and opportunities for deciphering signals from the noise.
Michelle Heeney, Margaret H Frank
The Plant Cell, Volume 35, Issue 6, June 2023, Pages 1817–1833, https://doi.org/10.1093/plcell/koad063
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Chromosome-level Genome Assembly of Euphorbia peplus, a Model System for Plant Latex, Reveals that Relative Lack of Ty3 Transposons Contributed to Its Small Genome Size.
Arielle R Johnson, Yuanzheng Yue, Sarah B Carey, Se Jin Park, Lars H Kruse, Ashley Bao, Asher Pasha, Alex Harkess, Nicholas J Provart, Gaurav D Moghe, Margaret H Frank
Genome Biology and Evolution, Volume 15, Issue 3, March 2023, evad018, https://doi.org/10.1093/gbe/evad018
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2022
Integrated PET and confocal imaging informs a functional timeline for the dynamic process of vascular reconnection during grafting.
Frank, MH, Komarov, S, Wang, Q, Li, K, Hecking, M, Fowler, H, Ravenburg, C, Widmier, A, Johnson, A, Thomas, H, Coneva, V, Chitwood, DH, Tai, Y-C. (2022) In Review
Preprint on BioRxvi: https://doi.org/10.1101/2022.10.27.513862
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ColourQuant: a high-throughput technique to extract and quantify color phenotypes from plant images. Book chapter in High-Throughput Plant Phenotyping.
Li, M, Frank, MH, Migicovsky, Z (2022) Methods Mol Biol​ 2539:77-85. Editor: Dr. Argelia Lorence.
Preprint on ArXiv: https://arxiv.org/abs/1903.01652
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The evolutionary history of small RNAs in the Solanaceae.
Baldrich, P, Bélanger, S, Kong, S, Pokhrel, S, Tamim, S, Teng, C, Schiebout, C, Gurazada, SGR, Gupta, P, Patel, P, Nakano, M, Dusia, A, Meyers, BC, Frank, MH
Plant Physiology​ 2022, 189(2): 644-665. DOI: https://doi.org/10.1093/plphys/kiac089
Preprint on BioRxiv: https://doi.org/10.1101/2021.05.26.445884
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Gene regulatory networks for compatible versus incompatible grafts identify a role for SlWOX4 during junction formation.
Thomas, H*, Van den Broeck*, L, Spurney, R, Sozzani, R, Frank, M
(2022) The Plant Cell 34(1): 535-556. DOI: https://doi.org/10.1093/plcell/koab246
Preprint on BioRxiv: https://www.biorxiv.org/content/biorxiv/early/2021/02/27/2021.02.26.433082.full.pdf
2021
A quantitative dissection of color patterning in the foliar ornamental, coleus.
Li, M, Coneva, V, Clark, D, Chitwood, DH, Frank, MH
Plant Physiology 187(3): 1310-1324. DOI: https://doi.org/10.1093/plphys/kiab393
Preprint on BioRxiv. https://doi.org/10.1101/2021.01.11.426252
Growing a glue factory: open questions in laticifer development.
Johnson, A, Moghe, G, Frank MH
Current Opinion in Plant Biology 64: 102096
DOI: https://doi.org/10.1016/j.pbi.2021.102096
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Getting to the root of grafting-induced traits.
Williams, Brandon, Muhammad Umair Ahsan, and Margaret Frank
Current Opinion in Plant Biology 59: 101988. https://doi.org/10.1016/j.pbi.2020.101988
2020
Li Chengjie Chen, Hao Chen, Yi Zhang, Hannah R.Thomas, Margaret H.Frank, Yehua He, and Rui Xia (2020) TBtools - an integrative toolkit developed for interactive analyses of big biological data. Molecular Plant 13(8): 1194-1202. https://doi.org/10.1016/j.molp.2020.06.009
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Preprint on BioRxiv: https://www.biorxiv.org/content/10.1101/289660v3
Download TBtools HERE: https://github.com/CJ-Chen/TBtools/releases
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Daniel H. Chitwood, Joey Mullins, Zoë Migicovsky, Margaret H. Frank, Robert VanBuren, Jason P. Londo (2020) Vein-to-blade ratio is an allometric indicator of climate-induced changes in grapevine leaf size and shape.
BioRxiv 2020.05.20.106906; doi: https://doi.org/10.1101/2020.05.20.106906​
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Abigail E. Bryson et al. (2020) Composite modeling of leaf shape across shoots discriminates Vitis species better than individual leaves.
BioRxiv 2020.06.22.163899; doi: https://doi.org/10.1101/2020.06.22.163899​
2019
Li Li, M, Frank, MH, and Migicovsky, Z (2019) ColourQuant: a high-throughput technique to extract and quantify colour phenotypes from plant images. AriXiv http://arxiv.org/abs/1903.01652 and In Review for Springer Books
Thomas, HR and Frank, MH (2019) Connecting the pieces: uncovering the molecular basis for long-distance communication through plant grafting. New Phytologist. 223(2): 582-589.
DOI:10.1111/nph.15772
2018
Lee, J-Y and Frank, MH (2018) Plasmodesmata in phloem: different gateways for different cargoes. Current Opinion in Plant Biology 43:119-124
DOI: 10.1016/j.pbi.2018.04.014
Li, M, Frank, MH, Coneva, V, Mio, W, Topp, CN, and Chitwood, DH (2018) The persistent homology mathematical framework provides enhanced genotype-to-phenotype associations for plant morphology. Plant Physiology
DOI: 10.1104/pp.18.00104
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Li, M, An, H, Angelovici, R, Bagaza, C, Batushansky, A, Clark, L, Coneva, V, Donoghue, MJ, Edwards, E, Fajardo, D, Fang, H, Frank, MH, Gallaher, T, Gebken, S, Hill, T, Jansky, S, Kaur, B, Klahs, PC, Klein, LL, Kuraparthy, V, Londo, J, Migicovsky, Z, Miller, A, Mohn, R, Myles, S, Otoni, WC, Pires, JC, Rieffer, E, Schmerler, S, Spriggs, E, Topp, CN, Van Deynze, A, Zhang, K, Zhu, L, Zink, BM, and Chitwood DH (2018) Topological Data Analysis as a Morphometric Method: Using Persistent Homology to Demarcate a Leaf Morphospace. Frontiers in Plant Science 553
DOI: 10.3389/fpls.2018.00553
2015-2017
2017
Coneva, V, Frank, MH, de Luis Balaguer, MA, Sozzani, R, and Chitwood, DH (2017) Genetic architecture and molecular networks underlying leaf thickness in desert-adapted tomato Solanum pennellii. Plant Physiology 175(1):376-391.
DOI: 10.1104/pp.17.00790
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Andres, RJ, Coneva, V, Frank, MH, Tuttle, JR, Han, S-W, Samayoa, LF, Kaur, B, Zhu, L, Fang, H, Bowman, DT, Rojas- Pierce, M, Haigler, CH, Jones, DC, Holland, JB, Chitwood, DH, and Kuraparthy, V. Modifications to a LATE MERISTEM IDENTITY-1 gene are responsible for the major leaf shapes of Upland cotton (Gossypium hirsutum L.). Proceedings of the National Academy of Sciences Plus 114(1):E57-E66.
DOI: 10.1073/pnas.1613593114
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2016
Frank, MH and Chitwood, DH (2016) Plant Chimeras: the good, the bad, and the ‘Bizzaria’. Developmental Biology 419: 41-53.
DOI: 10.1016/j.ydbio.2016.07.003
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Warschefsky, EJ, Klein, LL, Frank, MH, Chitwood, DH, Londo, JP, von Wettberg, EJB, and Miller, AJ (2016) Rootstocks: Diversity, Domestication, and Impacts on Shoot Phenotypes. Trends in Plant Science 21: 418-37.
DOI: 10.1016/j.tplants.2015.11.008
2015
Frank, MH and Scanlon, MJ (2015) Cell-Specific Transcriptomic Analyses of 3-Dimensional Shoot Development in the moss Physcomitrella patens. The Plant Journal 83: 743-751.
DOI: 10.1111/tpj.12928
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Frank, MH, Edwards, MB, Schultz, ER, McKain, MR, Fei, Z, Sorensen, I, Rose, JKC, Scanlon, MJ (2015) Dissecting the molecular signatures of apical cell-type shoot meristems from two ancient land plant lineages. New Phytologist 207: 893-904.
DOI: 10.1111/nph.13407
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Frank, MH and Scanlon MJ (2015) Transcriptomic Evidence for the Evolution of Shoot Meristem Function in Sporophyte-Dominant Land Plants through Concerted Selection of Ancestral Gametophytic and Sporophytic Genetic Programs. Molecular Biology and Evolution 32: 355-367.
DOI: 10.1093/mol- bev/msv182